广东省医学科学院

PI 团队杰出人才

廉哲雄实验室

廉哲雄

广东省人民医院/广东省医学科学院廉哲雄教授实验室主要研究方向为自身免疫性疾病和肝脏慢性炎症性疾病的基础免疫学研究、肿瘤免疫学发病机制以及治疗靶点和免疫药物研发。实验室负责人廉哲雄教授于白求恩医科大学（现吉林大学白求恩医学部）获得医学学士学位，日本关西医科大学获医学博士学位。曾为美国纽约大学北岸医院助理研究员、美国加利福尼亚大学戴维斯分校博士后、美国加利福尼亚大学戴维斯分校资深研究员、美国加利福尼亚大学戴维斯分校副教授。2009年作为中国科学院“百人计划”引进人才受聘于中国科技大学生命科学学院／免疫所，入选2009年度“教育部长江计划特聘教授”。后任职于华南理工大学医学院/生命科学研究院，现为广东省人民医院/广东省医学科学院副院长。回国以来主持并参与多项国家自然科学基金及科技部973项目，包括国自然面上项目1项，国自然重点项目3项，973子课题两项。并作为主持人获得广东省“珠江人才计划”第七批引进创新团队项目。廉哲雄教授团队长期从事自身免疫性疾病及肿瘤免疫等免疫学机制研究，尤其在肝脏自身免疫性疾病免疫学研究方面有较高国际声望。在J.Exp.Med., J.C.I., Gastroenterology, Hepatology, Journal of autoimmunity, J.Immunol.等杂志发表SCI论文一百六十余篇。

实验室成员介绍：

廉哲雄李鑫李亮赵志斌高采月晏凯龙杰黄荣荣王菲苏建玲王涵徐雅菲马金粉罗攀月刘梦楚达甜甜马敏卞振华游幸杜婉珊朱昊贤黄钏陈晓敏王宝如王晓庆周雪珂邓梦雪

实验室学术亮点：

1）创新性地构建了多种用于模拟人类自身免疫性疾病的模型小鼠，结合临床需求，利用模型小鼠对自身免疫性疾病免疫学发病机制进行了系统研究，为多种自身免疫性疾病的治疗提供了重要线索；

2）具有全面的多组学及生物信息学研究分析手段，利用高参数流式细胞术，单细胞转录组/免疫组库测序，多色免疫组化，基于质谱的代谢组/蛋白组学等多组学技术，研究疾病发生发展过程中细胞生物学分子生物学机制，对肿瘤免疫微环境及调控机制进行了深入探究，为临床转化提供相关依据。

代表性论文：

1) Xu T, Zhu HX, You X, Ma JF, Li X, Luo PY, Li Y*, Lian ZX*, Gao CY*. Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren's syndrome. JCI Insight. 2023 Apr 24;8(8):e167490.

2) Wang F, Long J, Li L, Wu ZX, Da TT, Wang XQ, Huang C, Jiang YH, Yao XQ, Ma HQ*, Lian ZX*, Zhao ZB*, Cao J*. Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer. Sci Adv. 2023 Jun 16;9(24):eadf5464.

3) Long J, Yang SY, Huang MX, Luo PY, Li L, Tsuneyama K, Ansari AA, Lu L*, Gershwin ME*, Lian ZX*, Zhao ZB*. Spontaneous development of an autoimmune hepatitis - primary biliary cholangitis overlap syndrome in dnTGFβRII Aire-/- mice. J Pathol. 2023 Jun;260(2):222-234.

4) Wang Q, Bu QF, Liu M, Zhang R, Gu J, Li L, Zhou J-R, Liang Y, Su W-T, Wang M-M, Lian Z-X*, Lu L*, Zhou H-M*.(2022) XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression. JHEP Rep 18;4(11):100555.

5) Han Y, Bian Z-H, Yang S-Y, Wang C-B, Li L, Yang Y-Q, Ansari AA, Gershwin ME, Zeng X-F*, Lian Z-X*, Zhao Z-B*.(2022) Single-Cell Characterization of Hepatic CD8+ T Cells in a Murine Model of Primary Biliary Cholangitis. Front Immunol. 20;13:860311.

6) Yang S-Y, Long J, Huang M-X, Luo P-Y, Bian Z-H, Xu Y-F, Wang C-B, Yang S-H, Li L, Selmi C, Gershwin ME, Zhao Z-B*, Lian Z-X*. (2021) Characterization of Organ-Specific Regulatory B Cells Using Single-Cell RNA Sequencing. Front Immunol. 14;12:711980.

7) Yao Y, Ma J-F, Chang C, Xu T, Gao C-Y*, Gershwin ME, Lian Z-X*.(2021) Immunobiology of T Cells in Sjögren's Syndrome. Clin Rev Allergy Immunol. 60(1):111-131.

8) Wang S-R, Hu R-D, Ma M, You X, Cui H, He Y, Xu D, Zhao Z-B, Selmi C, Eric Gershwin M, Li L*, Lian Z-X*. (2020) FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression. Mucosal Immunol. 15(3):459-470.

9) Yan K, Da T-T, Bian Z-H, He Y, Liu Q-Z, Long J, Li L, Gao C-Y, Yang S-H, Zhao Z-B*, Lian Z-X*. (2020) Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming. Cell death & disease 11(9): 178-189.

10) Zhao Z-B, Lu F-T, Ma H-D, Wang Y-H, Yang W, Long J, Miao Q, Zhang W, Tian Z, Ridgway WM, Cao J*, Gershwin ME*, Lian Z-X*. (2019) Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4(+) T cells. Cell Mol Immunol 17(2): 178-189.

11) Yin T-T, Zhao Z-B, Guo J, Wang T, Yang J-B, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian Z-X* and Yang Z*. (2019) Aurora A kinase inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Research. 79:3431.

12) Gao C-Y, Yao Y, Li L, Yang S-H, Chu H, Tsuneyama K, Li X-M*, M. Eric Gershwin ME and Lian Z-X*. (2019) Tissue Resident Memory CD8+T Cells acting as mediators of Salivary Gland Damage Mediated by in murine model of Sjögren’s Syndrome. Arthritis & Rheumatology. 71:121.

13) Yang J-B, Zhao Z-B, Liu Q-Z, Hu T-D, Long J, Yan K and Lian Z-X*. (2018) FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor associated macrophages. Oncogene. 37:1192-1204.

14) Tang W, Zhao Z-B, Wu C, Yang J-B, Zhou R, Lian Z-X* and Liang G*. (2018) Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Anti-Hepatic Fibrosis Effect. ACS Nano 12:9967.

15) Lu F-T, Yang W, Wang Y-H, Ma H-D, Tang W, Yang J-B, Li L, Ansari AA and Lian Z-X*. (2015) Thymic B cells promote regulatory T cell development and proliferation. J Autoimmunity. 61:62-72.

16) Yao Y, Yang W, Yang Y-Q, Ma H-D, Lu F-T, Li L, Tao Y-Y, Tsuneyama K, Zhang W, Friedman S, Gershwin ME and Lian Z-X*. (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice. J Autoimmunity. 51:99-108.

17) Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung P, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian Z-X*, Flavell R, He XS and Gershwin ME*. (2013) Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice. Hepatology. 57:806-16.

实验技术亮点：

1）流式细胞术

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