高采月
理学博士
- 教育/工作经历:
- 主要研究方向:
主要从事自身免疫性疾病的免疫学发病机制及调控研究,重点探究CD8+T细胞在自身免疫性疾病中特征、功能及与组织微环境的交流。相关工作发表在JCI Insight、Arthritis & Rheumatology、Clinical Reviews in Allergy & Immunology等期刊上。
- 研究关键词(中英文)
理学博士
主要从事自身免疫性疾病的免疫学发病机制及调控研究,重点探究CD8+T细胞在自身免疫性疾病中特征、功能及与组织微环境的交流。相关工作发表在JCI Insight、Arthritis & Rheumatology、Clinical Reviews in Allergy & Immunology等期刊上。
主持科研课题
1、国家自然科学基金委青年基金,81901653,2020.01-2022.12,20万,主持
代表性论文
(1) Ting Xu#, Hao-Xian Zhu#, Xing You#, Jin-Fen Ma, Xin Li, Pan-Yue Luo, Yang Li*, Zhe-Xiong Lian*, and Cai-Yue Gao*. Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren’s syndrome. JCI Insight. 2023; 8 (8): e167490.
(2) Yuan Yao#, Jin-Fen Ma#, Christopher Chang, Ting Xu, Cai-Yue Gao*, M. Eric Gershwin, Zhe-Xiong Lian*. Immunobiology of T cells in Sjögren’s syndrome. Clinical Reviews in Allergy & Immunology, 2021, 60: 111–131.
(3) Gao, C. Y.*, Yao, Y., Li, L., Yang, S. H., Chu, H., Tsuneyama, K, Li XM, Gershwin ME, Lian ZX. Tissue-Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjogren's Syndrome. Arthritis Rheumatol, 2019. 71(1): p. 121-132.
(4) Du W#, Gao CY#, You X, Li L, Zhao ZB, Fang M, Ye Z, Si M, Lian ZX, Yu X*. Increased proportion of follicular helper T cells is associated with B cell activation and disease severity in IgA nephropathy. Front Immunol. 2022 Aug 2; 13: 901465.
(5) Xing You#, Qiong Yang#, Kai Yan, Song-Rong Wang, Rong-Rong Huang, Shun-Qing Wang, Cai-Yue Gao*, Liang Li*, Zhe-Xiong Lian*.Multi-Omics Profiling Identifies Pathways Associated With CD8+ T-Cell Activation in Severe Aplastic Anemia. Front Genet. 2022 Jan 4; 12: 790990.