主持科研项目:
(1) 国家自然科学基金, 青年项目, Cbl家族蛋白通过调控Icos表达及下游信号通路控制Tfh细胞发育的分子机制研究, 2023-01 至 2025-12, 30万元, 主持
(2) Cole Foundation, Postdoctoral fellowship, The impact of Cbl-mediated post transcripti onal regulatory mechanism on B cell lymphomagensis, 2020-07 至 2022-06, 20万元, 主持
(3) Mcgill University Health Centre Research Institute (RI-MUHC), Postdoctoral fellowship, The impact of BCG-mediated immunity on the gut/bone marrow/lung axis and resistance to pulmonar y infections, 2020-01 至 2020-12, 9.1万元, 主持
代表性论文:
(1) Xin Li#; Adeline Gadzinsky; Liying Gong; Haijun Tong; Virginie Calderon; Yue Li; Daisuke K itamura; Ulf Klein; Wallace Y. Langdon; Fajian Hou; Yong-Rui Zou; Hua Gu*; Cbl ubiquitin ligases control B cell exit from the germinal-center reaction, Immunity, 2018, 48(3): 530-541
(2) Xin Li*; Liying Gong; Hua Gu* ; Regulation of immune system development and function by Cbl -mediated ubiquitination, Immunological Reviews, 2019, 291(1): 123-133
(3) Xin Li#; Liying Gong; Alexandre P. Meli; Danielle Karo-Atar; Weili Sun; Yongrui Zou; Irah L. King; Hua Gu*; Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing, Journal of Experimental Medicine, 2020, 217(9): e20191537
(4) Haijun Tong#; Xin Li#; Jinping Zhang; Liying Gong; Weili Sun; Virginie Calderon; Xiaochen Z hang; Yue Li; Adeline Gadzinski; Wallace Y. Langdon; Boris Reizis; Yongrui Zou; Hua Gu* ; Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells, Fronti ers in Immunology, 2021 Sep 23;12:757231
(5) Dominique Davidson*; Ming-Chao Zhong; Pier Paolo Pandolfi; Silvia Bolland; Ramnik J. Xavie r; Brian Seed; Xin Li; Hua Gu; Andre Veillette* ; The Csk-associated adaptor PAG inhibits effector T cell activation in cooperation with phosphatase PTPN22 and Dok adaptors, Cell Report, 2016, 17( 10): 2776-2788