李鑫

博士、研究员

教育/工作经历:
蒙特利尔大学获得微生物与免疫学博士,随后在麦吉尔大学从事博士后训练,于2022年5月以研究员身份加入基础医学研究部。
主要研究方向:
主要聚焦抗体介导的体液免疫反应、生发中心反应分子调控机制及自身抗议介导自身免疫病致病机制研究,具有丰富的经验及科研成果,作为第一作者或通讯作者在Immunity、Journal of Experimental Medicine, Immunological Reviews等杂志发表学术论文,工作多次被F1000推荐且被Nature Reviews Immunology和 Journal of Experimental Medicine点评文章推荐。
研究关键词(中英文)

主持科研项目:

(1) 国家自然科学基金, 青年项目, Cbl家族蛋白通过调控Icos表达及下游信号通路控制Tfh细胞发育的分子机制研究, 2023-01 至 2025-12, 30万元, 主持

(2) Cole Foundation, Postdoctoral fellowship, The impact of Cbl-mediated post transcripti onal regulatory mechanism on B cell lymphomagensis, 2020-07 至 2022-06, 20万元, 主持

(3) Mcgill University Health Centre Research Institute (RI-MUHC), Postdoctoral fellowship, The impact of BCG-mediated immunity on the gut/bone marrow/lung axis and resistance to pulmonar y infections, 2020-01 至 2020-12, 9.1万元, 主持

代表性论文:

(1) Xin Li#; Adeline Gadzinsky; Liying Gong; Haijun Tong; Virginie Calderon; Yue Li; Daisuke K itamura; Ulf Klein; Wallace Y. Langdon; Fajian Hou; Yong-Rui Zou; Hua Gu*; Cbl ubiquitin ligases control B cell exit from the germinal-center reaction, Immunity, 2018, 48(3): 530-541

(2) Xin Li*; Liying Gong; Hua Gu* ; Regulation of immune system development and function by Cbl -mediated ubiquitination, Immunological Reviews, 2019, 291(1): 123-133

(3) Xin Li#; Liying Gong; Alexandre P. Meli; Danielle Karo-Atar; Weili Sun; Yongrui Zou; Irah L. King; Hua Gu*; Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing, Journal of Experimental Medicine, 2020, 217(9): e20191537

(4) Haijun Tong#; Xin Li#; Jinping Zhang; Liying Gong; Weili Sun; Virginie Calderon; Xiaochen Z hang; Yue Li; Adeline Gadzinski; Wallace Y. Langdon; Boris Reizis; Yongrui Zou; Hua Gu* ; Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells, Fronti ers in Immunology, 2021 Sep 23;12:757231

(5) Dominique Davidson*; Ming-Chao Zhong; Pier Paolo Pandolfi; Silvia Bolland; Ramnik J. Xavie r; Brian Seed; Xin Li; Hua Gu; Andre Veillette* ; The Csk-associated adaptor PAG inhibits effector T cell activation in cooperation with phosphatase PTPN22 and Dok adaptors, Cell Report, 2016, 17( 10): 2776-2788