刘居理

博士、副研究员

教育/工作经历:
博士毕业于中国科学院-广州生物医药与健康研究院,博士毕业后分别于美国University of Pittsburgh School of Medicine (Department of developmental biology) 和Indiana University School of Medicine (Pediatrics department) 完成博士后训练,后于美国Indiana University School of Medicine (Pediatrics department) 担任助理教授,目前全职工作于广东省人民医院(广东省医学科学院)-医学研究部,担任副研究员。
主要研究方向:
【1】心脏发育、心肌细胞形成/损伤/再生;
【2】人类遗传相关心脏病体外模拟及致病机制;
研究关键词(中英文)

主要获奖情况

12017-2018 American Heart Association Postdoctoral Fellowship

22018 American Heart Association-5th ACRE/APS, Outstanding Young Investigator Award

32020 American Heart Association Paul Dudley White International Scholar Award

42018广东省自然科学技术奖一等奖

52022国家优青(海外)项目

 

主持科研课题

1】国家优青(海外)项目,2023-2025年,主持

2】国自然-面上项目,2023-2026年,主持

3广东省人民医院高层次引进人才项目,2023-2027年,主持

 

代表性论文

1Juli Liu, Yucheng Zhang, Lei Han, Shuai Guo, Shiyong Wu, Emma Helen Doud, Cheng Wang, Hanying Chen, Michael Rubart-von der Lohe, Jun Wan, Lei Yang*.Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes. Stem Cell Reports. 2022;17(3):522-537.

2Juli Liu, Sheng Liu, Lei Han, Yi Sheng, Il-Man Kim, Jun Wan, Lei Yang*. LncRNA HBL1 is Required for Genome-Wide PRC2 Occupancy and Function in Cardiogenesis from Human Pluripotent Stem Cells. Development. 2021;148(13):dev199628.

3Juli Liu, Sheng Liu, Hongyu Gao, Lei Han, Xiaona Chu, Yi Sheng, Weinian Shou, Yue Wang, Yunlong Liu, Jun Wan, Lei Yang *. Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells. Genome Biology. 2020;21(1):169.

4Juli Liu, Yang Li, Bo Lin, Yi Sheng, Lei Yang*. HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Developmental Cell. 2017; 43, 372.

5Shaoxian Chen, Yueheng Wu, Xianyu Qin, Pengju Wen, Juli Liu*, Min Yang*. Global gene expression analysis using RNA-seq reveals the new roles of Panax notoginseng Saponins in ischemic cardiomyocytes. Journal of Ethnopharmacology. 2021;268:113639.