主持科研课题
国家自然科学基金青年项目，61903277，基于生物学通路活性在单细胞转录组层面解析肿瘤细胞异质性的研究，2020.01 - 2022.12，27万，主持

代表性论文

(1). Yan Zhang^†, Yaru Zhang^†, Jun Hu^†, Ji Zhang, Fangjie Guo, Meng Zhou, Guijun Zhang, Fulong Yu, Jianzhong Su (2020) scTPA: a web tool for single-cell transcriptome analysis of pathway activation signatures. Bioinformatics. (IF=6.931)

(2). Yan Zhang^†, Xin Li^†, Dianshuang Zhou, et al. (2018) Inferences of individual drug responses across diverse cancer types using a novel competing endogenous RNA network. Molecular oncology (IF=7.449)

(3). Pingzhu Zhou^†, Yan Zhang^†, Isha Sethi, Lincai Ye, Michael A. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, Bin Zhou, William T. Pu^* (2022) GATA4 Regulates Developing Endocardium Through Interaction with ETS1. Circulation research (IF=23.213)

(4). Hui Liu^†, Yan Zhang^†, You-You Zhang, Yan-Ping Li, Zi-Qi Hua, Chang-Jun Zhang, Kun-Chao Wu, Fulong Yu, Yaru Zhang, Jianzhong Su^*, Zi-Bing Jin^* (2020) Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin. Proceedings of the National Academy of Sciences (PNAS) (IF=11.205)

(5). Yan Zhang^†, Dianming Liu^†, Lihong Wang, et al. (2015) Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease. Journal of molecular medicine (IF=5.314)

(6). Yan Zhang^†, Zhengbo Xue^†, Fangjie Guo^†, Fulong Yu, Liangde Xu^* and Hao Chen^* (2020) Nc2Eye: a curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases. Front. Cell Dev. Biol. (IF=6.684)

(7). Yan Zhang^†, Fulong Yu^†, Siqi Bao and Jie Sun^* (2019) Systematic characterization of circular RNA-associated ceRNA network identified novel circRNA biomarkers in Alzheimer’s disease. Frontiers in Bioengineering and Biotechnology (IF=5.89)

(8). Fulong Yu^†, Fei Quan^†, Jinyuan Xu^†, Yan Zhang^†, Yi Xie, et al. (2018) Breast cancer prognosis signature: linking risk stratification to disease subtypes. Briefings in bioinformatics (IF=11.622)

(9). Wei Jiang^†, Yan Zhang^†, Fanlin Meng, et al. (2013) Identification of active transcription factor and miRNA regulatory pathways in Alzheimer’s disease. Bioinformatics (IF=6.931)

(10). Yangpo Cao^†, Xiaoran Zhang^†, Brynn Akerberg^†, Hai-Yun Yuan, Tomoya Sakamoto, Feng Xiao, Nathan VanDusen, Pingzhu Zhou, Mason Sweat, Yi Wang, Jian Chen, Yan Zhang, Peizhe Wang, Daniel Kelly, William Pu^* (2022) In vivo dissection of chamber selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity. Circulation (IF=39.92)

(11). Fulong Yu^†, Kai Li^†, Shuangquan Li^†, Jiaqi Liu, Yan Zhang, et al. (2020) CFEA: a cell-free epigenome atlas in human diseases. Nucleic Acids Research (IF=19.16)