张串霞
理学博士、副研究员
- 教育/工作经历：
致力于从事恶性肿瘤信号分子通路研究及肿瘤精准治疗的新靶标筛选，近5年以第一作者（或共同第一作者）在Cell death and differentiation、Cell reports、Oncogenesis等SCI期刊发表文章4篇，主持国家自然科学基金青年科学基金项目1项，主持广东省自然科学基金项目2项。
- 主要研究方向：
- 研究关键词（中英文）
主持科研课题
1、国家自然科学基金青年项目，82103661，HOXB3主导的核心转录调控环路维持胶质母细胞瘤干性的机制研究，2022.01-2024.12，30万，主持
2、广东省自然科学基金，2019A1515110147，USP33在胶质母细胞瘤中作为肿瘤抑制子的机制研究，2020.01-2022.12，10万，主持
3、广东省自然科学基金，2018A030310159，USP4激活STAT3信号通路促进神经胶质瘤生长的机制研究，2018.05-2020.04，10万，主持
代表性论文
(1) Zhang, Chuanxia; Ye, Shubiao; Ni, Jianjiao; Cai, Tingting; Liu, Yina; Huang, Daijia; Mai, Haiqiang; Chen, Qiuyan; He, Jia; Zhang, Xiaoshi; Zeng, Yixin; Li, Jiang; Cui, Jun ; STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion, Cell Death and Differentiation, 2019, 26(11): 2314-2328 (IF=15.828)
(2) Zhang, Chuanxia; Huang, Daijia; Baloche, Valentin; Zhang, Lin; Xu, Jingxiao; Li, Bowen; Zhao, Xinrui; He, Jia; Mai, Haiqiang; Chen, Qiuyan; Zhang, Xiaoshi; Busson, Pierre; Cui, Jun; Li, Jiang ; Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING deg
radation, Oncogenesis, 2020, 9(7): 65-79 (IF=7.485)
(3) Liu Kunpeng; Zhang Chuanxia; Li Bowen; Xie Weihong; Zhang Jindong; Nie Xichen; Tan Peng; Zheng Limin; Wu Song; Qin Yunfei; Cui Jun; Zhi Feng ; Mutual Stabilization between TRIM9 Short Is oform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression, Cell Reports, 2018, 23(3): 838-851 (IF=9.423)
(4) Zhang, Jindong; Zhang, Chuanxia; Cui, Jun; Ou, Jiayu; Han, Jing; Qin, Yunfei; Zhi, Feng; Wang, Rong-Fu ; TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination, Cell Death & Disease, 2017, 8 (IF=8.469)