主持科研课题

1. 基于高通量测序技术转录后调控复杂性进化模型及平台的构建 (国家自然科学基金青年项目，2015，主持)

2. 单细胞多维数据解析拷贝数变异驱动的肿瘤耐药基因调控机制 (国家自然科学基金面上项目，2021，主持)

发表文章

1. Beth A. Helmink#, Sangeetha M. Reddy#, Jianjun Gao#, Shaojun Zhang#, Rafet Basar, Rohit Thakur, Keren Yizhak, Moshe Sade-Feldman, Jorge Blando, Guangchun Han, Vancheswaran Gopalakrishnan, Yuanxin Xi, Hao Zhao, Rodabe N. Amaria, Hussein A. Tawbi, Alex P. Cogdill, Wenbin Liu, Valerie S. LeBleu, Fernanda G. Kugeratski, Sapna Patel, Michael A. Davies, Patrick Hwu, Jeffrey E. Lee, Jeffrey E. Gershenwald, Anthony Lucci, Reetakshi Arora, Scott Woodman, Emily Z. Keung, Pierre-Olivier Gaudreau, Alexandre Reuben, Christine N. Spencer, Elizabeth M. Burton, Lauren E. Haydu, Alexander J. Lazar, Roberta Zapassodi, Courtney W. Hudgens, Deborah A. Ledesma, SuFey Ong, Michael Bailey, Sarah Warren, Disha Rao, Oscar Krijgsman, Elisa A. Rozeman, Daniel Peeper, Christian U. Blank, Ton N. Schumacher, Lisa H. Butterfield, Monika A. Zelazowska, Kevin M. McBride, Raghu Kalluri, James Allison, Florent Petitprez, Wolf Herman Fridman, Catherine Sautès-Fridman, Nir Hacohen, Katayoun Rezvani, Padmanee Sharma, Michael T. Tetzlaff, Linghua Wang & Jennifer A. Wargo; B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020 Jan;577(7791):549-555.(Co-first author, https://www.nature.com/articles/s41586-019-1922-8)

2. Fang Wang; Shaojun Zhang; Tae-Beom Kim; Yu-yu Lin; Ramiz Iqbal; Zixing Wang; Vakul Mohanty; Karnishka Sircar; Jose A. Karam; Michael C. Wendl; Funda Meric- Bernstam; John N. Weinstein; Li Ding; Gordon B. Mills; Ken Chen*; Integrated transcriptomic-genomic tool Texomer profiles cancer tissues, Nature Methods, 2019, 16:401-404. (https://www.nature.com/articles/s41592-019-0388-9)

3. Shaojun Zhang#, Changying Jiang#, Yuanxin Wang, Rongjia Zhang, Yang Liu, Joseph McIntosh, Guangchun Han, Ruiping Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Lee, Raphael Steiner, Jorge Romaguera, Preetesh Jain, Krystle Nomie, Andrew Futreal1, Linghua Wang* & Michael Wang*; Longitudinal Single-Cell Transcriptome Profiling Reveals Clonal Evolution and Strategies to Overcome Therapeutic Resistance in Mantle Cell Lymphoma. Nature Communication, 2021 May 17;12(1):2877 (https://www.nature.com/articles/s41467-021-22872-z)

4. Liang Zhang#, Yixin Yao#, Shaojun Zhang#, Yang Liu, Hui Guo, Makhdum Ahmed, Taylor Bell, Hui Zhang, Guangchun Han, Elizabeth Lorence, Maria Badillo, Shouhao Zhou, Yuting Sun, M. Emilia Di Francesco, Ningping Feng, Randy Haun, Renny Lan, Samuel G.Mackintosh, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Lan V. Pham, Philip L. Lorenzi, Joseph Marszalek, Tim Heffernan, Giulio Draetta, Philip Jones, Andrew Futreal, Krystle Nomie, Linghua Wang* & Michael Wang*: Metabolic reprogramming towards OXPHOS identifies a novel therapeutic target for mantle cell lymphoma. Sci Transl Med. 2019 May 8;11(491) (Co-first author, https://stm.sciencemag.org/content/11/491/eaau1167.short)E. Birkeland, S. Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza-Zepeda, E. Hovig, O. Myklebost, S. Knappskog & P. E. Lønning; Patterns of genomic evolution in advanced melanoma; Nature Communication,  2018 Jul 10;9(1):2665. (https://www.nature.com/articles/s41467-018-05063-1)

5. Fang Wang#; Shaojun Zhang#; Yanhua Wen#; Yanjun Wei; Haidan Yan; Hui Liu; Jianzhong Su; Yan Zhang*; Jianhua Che*; Revealing the architecture of genetic and epigenetic regulation: a maximum likelihood model; Briefing in Bioinformatics, 2014, 15:1028-4 (https://academic.oup.com/bib/article/15/6/1028/181097)

6. Ruiping Wang, Minghao Dang, Kazuto Harada, Guangchun Han, Fang Wang, Melissa Pool Pizzi, Meina Zhao, Ghia Tatlonghari, Shaojun Zhang, Dapeng Hao, Yang Lu, Shuangtao Zhao, Brian D. Badgwell, Mariela Blum Murphy, Namita Shanbhag, Jeannelyn S. Estrella, Sinchita Roy-Chowdhuri, Ahmed Adel Fouad Abdelhakeem, Yuanxin Wang, Guang Peng, Samir Hanash, George A. Calin, Xingzhi Song, Yanshuo Chu, Jianhua Zhang, Mingyao Li, Ken Chen, Alexander J. Lazar, Andrew Futreal, Shumei Song, Jaffer A. Ajani & Linghua Wang; Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma; Nature Medicine, 2021 Jan;27(1):141-151. (https://www.nature.com/articles/s41591-020-1125-8)

7. Edoardo Del Poggetto, I-Lin Ho, Chiara Balestrieri, Er-Yen Yen, Shaojun Zhang, Francesca Citron, Rutvi Shah, Denise Corti, Giuseppe R. Diaferia, Chieh-Yuan Li, Sara Loponte, Federica Carbone, Yoku Hayakawa, Giovanni Valenti, Shan Jiang, Luigi Sapio, Hong Jiang, Prasenjit Dey, Sisi Gao, Angela K. Deem, Stefan Rose-John, Wantong Yao, Haoqiang Ying, Andrew D. Rhim, Giannicola Genovese, Timothy P. Heffernan, Anirban Maitra, Timothy C. Wang, Linghua Wang, Giulio F. Draetta, Alessandro Carugo, Gioacchino Natoli, Andrea Viale. Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science, 2021; 373 (6561) DOI: 10.1126/science.abj0486 

8. Yuchao He, Linlin Zhan, Jian Shi, Manyu Xiao, Ran Zuo, Chengmeng Wang, Zhiyong Liu, Wenchen Gong, Liwei Chen, Yi Luo, Shaojun Zhang, Youwei Wang, Lu Chen, Hua Guo. The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma. Adv Sci (Weinh). 2023 Jun; 10(18): 2207650.