汪崇文

工学博士、副教授/硕导

教育/工作经历:
2023.5-至今,广东省人民医院,检验科,副研究员
2019/07-至今,徐州医科大学,检验技术学院,兼职硕导
2018/07-2023.3,安徽农业大学,生命科学学院,副教授,硕导
2019/10-2022.12,军事科学院军事医学研究院,博士后,合作导师:王升启/王林
2014/09-2018/07,北京工业大学,生物医学工程,博士,导师:王升启
主要研究方向:
从事分子诊断与分子识别新技术、免疫层析现场检测及病原微生物快速检测等方面的研究。开发出系列超敏免疫层析检测新材料与新技术,实现复杂环境样本、临床样本中病原微生物(细菌、病毒)、生物标志物、毒素(真菌毒素、战剂毒素)、新型冠状病毒抗原及其IgM/IgG抗体等目标物的高灵敏快速检测。2020年紧急研发的新冠抗体IgM/IgG联合检测试剂盒(量子点法)获国家医疗器械证书(国械注准20203400536)及军队特许药品批件(军药准字Q2020002)。以第一作者(排名第一)/通讯作者在......
研究关键词(中英文)

主要研究方向:

从事分子诊断与分子识别新技术、免疫层析现场检测及病原微生物快速检测等方面的研究。开发出系列超敏免疫层析检测新材料与新技术,实现复杂环境样本、临床样本中病原微生物(细菌、病毒)、生物标志物、毒素(真菌毒素、战剂毒素)、新型冠状病毒抗原及其IgM/IgG抗体等目标物的高灵敏快速检测。2020年紧急研发的新冠抗体IgM/IgG联合检测试剂盒(量子点法)获国家医疗器械证书(国械注准20203400536)及军队特许药品批件(军药准字Q2020002)。以第一作者(排名第一)/通讯作者在Biosens Bioelectron6篇,IF 12.5),Chemical Engineering Journal 2篇,IF 16.7),Analytical ChemistryNano Res(卓越计划-领军期刊,IF 10.3),Journal of Hazardous Materials2篇,IF 14.4),ACS Appl. Mater. Interfaces5篇,IF 10.3),Sens. Actuators B-Chem.6篇,IF 9.22)等知名SCI期刊发表论文51篇(中科院一区32篇),10分以上的14篇,入选ESI高被引论文5篇,H-index29,论文总被引超过2400次。
主要学术任职
1、中国研究型医院学会生物标志物委员会委员,委员

2、中国医学装备协会检验医学分会,委员

3、中国医疗器械行业协会现场快速检测(POCT)分会,委员
主要获奖情况
12016军队科技进步一等奖:生物战剂及新突发病原体检测新技术、新标准和新产品研究(排名7/14
主持科研课题
1. 国家自然科学基金青年科学基金项目,基于双色膜状磁性荧光标签编码的矩阵式免疫层析系统用于食源性细菌/病毒的高灵敏现场检测,2023.01-2025.1230万,主持,32200076

2. 国家重点研发计划,新冠病毒变异株快速检测新技术及便携式仪器研发子课题3:高敏量子点荧光层析试纸条及体系研发,2023.01-2023.1230万,主持,2022YFC0870100

3. 中国博士后科学基金新冠疫情防控专项资助,基于多通道SERS免疫层析的呼吸道病毒高灵敏联合检测新技术研究,2020.09-2022.0518万,主持,2020T130133ZX

4. 安徽省自然科学基金面上项目,基于多通道磁性量子点荧光免疫层析系统的高致病性呼吸道病毒快速高灵敏检测新技术研究2022.01-2024.1210万,主持,2208085MB29.

5. 安徽省自然科学基金青年项目,基于SERS免疫层析的多种肝癌标志物联合检测新技术研究,2019.07-2021.0710万,主持,1908085QB85.

代表性论文

1. Tu J#, Wu T#, Yu Q, Li J, Zheng S, Qi K, Sun G*, Xiao R*, Wang C.* Introduction of multilayered magnetic core-dual shell SERS tags into lateral flow immunoassay: A highly stable and sensitive method for the simultaneous detection of multiple veterinary drugs in complex samples. J Hazard Mater. 2023, 448, 130912. (中科院1区,IF 14.4,最后通讯)

2. Wang W, Yu Q, Zheng S, Li J, Wu T, Wang S*, Wang C*, Gu B*. Ultrasensitive and simultaneous monitoring of multiple small-molecule pollutants on an immunochromatographic strip with multilayered film-like fluorescent tags. Sci Total Environ. 2023, 878, 162968.(中科院1区,IF 10.7,共同通讯,广东省人民医院第一单位

3. Wang W, Yang X, Rong Z, Tu Z, Zhang X, Gu B*, Wang C*, Wang S*. Introduction of graphene oxide-supported multilayer-quantum dots nanofilm into multiplex lateral flow immunoassay: A rapid and ultrasensitive point-of-care testing technique for multiple respiratory viruses. Nano Res. 2023, 16(2), 3063. (中科院1区,卓越计划-领军期刊,IF 10.3,共同通讯)

4. Yang X, Yu Q, Cheng X, Wei H, Zhang X, Rong Z*, Wang C*, Wang S*. Introduction of Multilayered Dual-Signal Nanotags into a Colorimetric-Fluorescent Coenhanced Immunochromatographic Assay for Ultrasensitive and Flexible Monitoring of SARS-CoV-2. ACS Appl Mater Interfaces. 2023 Mar 8;15(9):12327-12338.(中科院2区,IF 10.2,共同通讯)

5. Wang, C.* ; Wang, C.; Li, J.; Tu, Z.; Gu B*.; Wang, S.*, Ultrasensitive and multiplex detection of four pathogenic bacteria on a bi-channel lateral flow immunoassay strip with three-dimensional membrane-like SERS nanostickers. Biosens Bioelectron. 2022, 214, 114525. (中科院一区,IF=12.5, 第一作者/通讯作者)

6. Zheng, S.; Wang, C.; Wang, W.; Li, J.; Yu, Q.; Wang, C.*; Wang, S.*, Graphene Oxide-Based Three-Dimensional Au Nanofilm with High-density and Controllable Hotspots: A Powerful Film-Type SERS Tag for Immunochromatographic Analysis of Multiple Mycotoxins in Complex Samples. Chem Eng J. 2022, 448, 137760.(中科院1区,IF=16.74共同通讯

7. Shen, W.; Wang, C.; Zheng, S.; Jiang, B.; Li, J.; Pang, Y.; Wang, C.*; Hao, R.*; Xiao, R.*, Ultrasensitive multichannel immunochromatographic assay for rapid detection of foodborne bacteria based on two-dimensional film-like SERS labels. J. Hazard. Mater. 2022, 437, 129347. (中科院一区,IF 14.4,通讯作者)

8. Cheng X, Zheng S, Wang W, Han H, Yang X, Wang C.*, Wang S*. Synthesis of two-dimensional graphene oxide-fluorescent nanoprobe for ultrasensitive and multiplex immunochromatographic detection of respiratory bacteria. Chem Eng J 2021, 426, 131836. (中科院一区,IF=16.7,通讯作者)

9. Wang C.*, Cheng X, Liu L, Zhang X, Yang X, Zheng S, Rong Z, Wang S*. Ultrasensitive and Simultaneous Detection of Two Specific SARS-CoV-2 Antigens in Human Specimens Using Direct/Enrichment Dual-Mode Fluorescence Lateral Flow Immunoassay. ACS Appl Mater Interfaces. 2021, 13, 40342-40353. (中科院一区,IF=10.38,第一作者/通讯作者)

10. Pang Y, Shi J, Yang X, Wang C*, Sun Z*, Xiao R*. Personalized detection of circling exosomal PD-L1 based on Fe3O4@TiO2 isolation and SERS immunoassay. Biosens Bioelectron. 2020,148:111800. (中科院一区,IF=12.5, 通讯作者,ESI高被引论文)

11. Xiao R, Lu L, Rong Z, Wang C*, Peng Y, Wang F, Wang J, Sun M, Dong J, Wang D, Wang L, Sun N, Wang S*. Portable and multiplexed lateral flow immunoassay reader based on SERS for highly sensitive point-of-care testing. Biosens Bioelectron. 2020 168, 112524. (中科院一区,IF=12.5, 通讯作者)

12. Wang C.; Xiao R.; Wang S.; Yang X.; Bai Z.; Li X.; Rong Z.*; Shen B.*; Wang S.*, Magnetic quantum dot based lateral flow assay biosensor for multiplex and sensitive detection of protein toxins in food samples. Biosens. Bioelectron. 2019, 146, 111754. (中科院一区,IF=12.5, 第一作者)

13. Wang C.; Wang C.; Wang X.; Wang K.; Zhu Y.; Rong Z.; Wang W.*; Xiao R.*; Wang S.*, Magnetic SERS Strip for Sensitive and Simultaneous Detection of Respiratory Viruses. ACS Appl. Mater. Interfaces. 2019, 11 (21), 19495-19505. (中科院一区, IF=10.38第一作者ESI高被引论文)

14. Pang Y.; Wang C.; Lu L.; Wang C.*; Sun Z.*; Xiao R.*, Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer. Biosens. Bioelectron. 2019, 130, 204-213. (中科院一区,IF=12.5, 通讯作者,ESI高被引论文)

15. Rong, Z.; Bai, Z.; Li, J.; Tang, H.; Shen, T.; Wang, Q.; Wang, C.*; Xiao, R.*; Wang, S.*, Dual-color magnetic-quantum dot nanobeads as versatile fluorescent probes in test strip for simultaneous point-of-care detection of free and complexed prostate-specific antigen. Biosens. Bioelectron. 2019, 145, 111719. (中科院一区,IF=12.5,共同通讯)

16. Wang C.*, Yang X, Gu B*, Liu H, Zhou Z, Shi L, Cheng X, Wang S.*, Sensitive and simultaneous detection of SARS-CoV-2-specific IgM/IgG using lateral flow immunoassay based on dual-mode quantum dot nanobeads, Anal. Chem. 2020, 92, 15542–15549. (中科院一区,IF=8.0, 第一作者/通讯作者,自然指数期刊)

17. Wang, C.; Shen, W.; Rong, Z.; Liu, X.; Gu B.*; Xiao R.*; Wang S.*, Layer-by-layer assembly of magnetic-core dual quantum dot-shell nanocomposites for fluorescence lateral flow detection of bacteria. Nanoscale. 2020, 12,795-807. (中科院一区, IF=8.3, 第一作者)

18. Wang C.*, Yang X, Zheng S, Cheng X, Xiao R*, Li Q, Wang W, Liu X, Wang S*. Development of an ultrasensitive fluorescent immunochromatographic assay based on multilayer quantum dot nanobead for simultaneous detection of SARS-CoV-2 antigen and influenza A virus. Sens Actuators B Chem. 2021, 345, 130372. (中科院一区,IF=9.22,第一作者/通讯作者)

19. Zheng. S, Wu. T, Li. J, Qin. J*, Xiao. R*, Wang. S*, Wang C.*, Difunctional immunochromatographic assay based on magnetic quantum dot for ultrasensitive and simultaneous detection of multiple mycotoxins in foods, Sens Actuators B Chem. 2022, 359, 131528. (中科院一区,IF 9.22最后通讯)

20. Han H, Wang C.*, Yang X, Zheng S, Cheng X, Liu Z, Zhao B*, Xiao R*. Rapid field determination of SARS-CoV-2 by a colorimetric and fluorescent dual-functional lateral flow immunoassay biosensor. Sens Actuators B Chem. 2022, 351, 130897. (中科院一区,IF 9.22共同通讯,ESI高被引论文)

21. Liu H, Dai E, Xiao R, Zhou Z, Zhang M, Bai Z, Shao Y, Qi K, Tu J*, Wang C*, Wang S*. Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples. Sens Actuators B Chem. 2021, 329, 129196. (中科院一区,IF=9.22,通讯作者,ESI高被引论文)