金国祥

PhD博士,研究员,博士生导师

教育/工作经历:
香港大学博士,香港大学、美国MD  Anderson 癌症中心博士后。曾任维克森林大学讲师、助理教授,陆军军医大学教授、博士生导师,现为广东省人民医院研究员,南方医科大学博士生导师。实验室负责人,主要研究肿瘤与衰老的分子机理及干预策略。主持国家自然科学基金面上项目3项,承担国家自然科学基金创新研究群体项目研究骨干任务1项。发表Nat Immunol 2018;Cell Res 2023; J Clin Invest 2022; Mol Cell 2015;EMBO J 2011;Commun Biol 2023; Cell Death Dis 2023等通讯或第一作者研究论文。Vinfuture Prize受邀提名人。
主要研究方向:
1. 肿瘤及其免疫微环境
2. 衰老的分子机理与干预策略
研究关键词(中英文)

主要科研项目:

1. 国家自然科学基金面上目,822731802023/01-2026/12,51万元,主持

2. 国家自然科学基金面上目,819727742020/01-2023/12,55万元,主持

3. 国家自然科学基金面上目,81773040,2018/01-2021/12,62万元,主持,已结题,

4. 国家自然科学基金创新研究群体项目,818210032019/1-2024/121050万元,研究骨干

5. 重庆市院士牵头科技创新引导专项cstc2018jcyj-yszxX0011,2018/10-2021/09,50万元,主持,已结题。

6. 广东省基础与应用基础研究基金区域联合基金—粤港澳研究团队项目,2021B1515130004,2021/10-2025/9, 200万元,核心成员(子课题负责人)

 

代表性论文:

1. Jin G#, Xu C#, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW*, Lin HK*. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol, 2018, 19(1): 29-40. IF=30.5

2. Xie XQ#, Yang Y, Wang Q, Liu HF, Fang XY, Li CL, Jiang YZ, Wang S, Zhao HY, Miao JY, Ding SS, Liu XD, Yao XH, Yang WT, Jiang J, Shao ZM, Jin G*, Bian XW*. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Res, 2023 Mar;33(3):215-228. IF=44.1

3. Zhang L#, He Y#, Jiang Y, Wu Q, Liu Y, Xie Q, Zou Y, Wu J, Zhang C, Zhou Z*, Bian XW*Jin G*. PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation. Cell Death Dis. 2023 Apr 1;14(4):233. IF=9

4. Zhang L#, Yu J#, Zheng M, Zhen H, Xie Q, Zhang C, Zhou Z*, Jin G*. RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation. Commun Biol, 2023 Feb 23;6(1):211. IF=5.9

5. Zhen H#, Huang M#, Zheng M#, Gao L, Guo Z, Pang Q*, Jin G*, Zhou Z*. WTAP regulates stem cells via TRAF6 to maintain planarian homeostasis and regeneration. Int J Biol Macromol. 2023 May 31:124932. IF=8.2

6. Jin W#, He Y, Li T, Long F, Qin X, Yuan Y, Gao G, Shakhawat HM, Liu X, Jin G*, Zhou Z*. Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm. Cell Biosci. 2022 Mar 15;12(1):31. IF=7.5

7. Xu C#*, Jin G#, Wu H#, Cui W#, Wang YH, Manne RK, Wang G, Zhang W, Zhang X, Han F, Cai Z, Pan BS, Hsu CC, Liu Y, Zhang A, Long J, Zou H, Wang S, Ma X, Duan J, Wang B, Liu W, Lan H, Xiong Q, Xue G, Chen Z, Xu Z, Furth ME, Haigh Molina S, Lu Y, Xie D*, Bian XW*, Lin HK*. SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling. J Clin Invest. 2022 Mar 1;132(5):e141797. IF=15.9

8. Jin G#, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov DD, Ho YS, Lin HK*. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino acid-dependent mTORC1 hyperactivation by recruiting GATOR1. Mol Cell, 2015, 58(6): 989-1000. IF=16

9. Jin G#, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z*, MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B-cell development. EMBO J, 2011, 30(11): 2281-2293. IF=11.4