主要科研项目:
1. 国家自然科学基金面上项目,82273180,2023/01-2026/12,51万元,主持
2. 国家自然科学基金面上项目,81972774,2020/01-2023/12,55万元,主持
3. 国家自然科学基金面上项目,81773040,2018/01-2021/12,62万元,主持,已结题,
4. 国家自然科学基金创新研究群体项目,81821003,2019/1-2024/12,1050万元,研究骨干
5. 重庆市院士牵头科技创新引导专项,cstc2018jcyj-yszxX0011,2018/10-2021/09,50万元,主持,已结题。
6. 广东省基础与应用基础研究基金区域联合基金—粤港澳研究团队项目,2021B1515130004,2021/10-2025/9, 200万元,核心成员(子课题负责人)
代表性论文:
1. Jin G#, Xu C#, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW*, Lin HK*. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol, 2018, 19(1): 29-40. IF=30.5
2. Xie XQ#, Yang Y, Wang Q, Liu HF, Fang XY, Li CL, Jiang YZ, Wang S, Zhao HY, Miao JY, Ding SS, Liu XD, Yao XH, Yang WT, Jiang J, Shao ZM, Jin G*, Bian XW*. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Res, 2023 Mar;33(3):215-228. IF=44.1
3. Zhang L#, He Y#, Jiang Y, Wu Q, Liu Y, Xie Q, Zou Y, Wu J, Zhang C, Zhou Z*, Bian XW*, Jin G*. PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation. Cell Death Dis. 2023 Apr 1;14(4):233. IF=9
4. Zhang L#, Yu J#, Zheng M, Zhen H, Xie Q, Zhang C, Zhou Z*, Jin G*. RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation. Commun Biol, 2023 Feb 23;6(1):211. IF=5.9
5. Zhen H#, Huang M#, Zheng M#, Gao L, Guo Z, Pang Q*, Jin G*, Zhou Z*. WTAP regulates stem cells via TRAF6 to maintain planarian homeostasis and regeneration. Int J Biol Macromol. 2023 May 31:124932. IF=8.2
6. Jin W#, He Y, Li T, Long F, Qin X, Yuan Y, Gao G, Shakhawat HM, Liu X, Jin G*, Zhou Z*. Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm. Cell Biosci. 2022 Mar 15;12(1):31. IF=7.5
7. Xu C#*, Jin G#, Wu H#, Cui W#, Wang YH, Manne RK, Wang G, Zhang W, Zhang X, Han F, Cai Z, Pan BS, Hsu CC, Liu Y, Zhang A, Long J, Zou H, Wang S, Ma X, Duan J, Wang B, Liu W, Lan H, Xiong Q, Xue G, Chen Z, Xu Z, Furth ME, Haigh Molina S, Lu Y, Xie D*, Bian XW*, Lin HK*. SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling. J Clin Invest. 2022 Mar 1;132(5):e141797. IF=15.9
8. Jin G#, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov DD, Ho YS, Lin HK*. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino acid-dependent mTORC1 hyperactivation by recruiting GATOR1. Mol Cell, 2015, 58(6): 989-1000. IF=16
9. Jin G#, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z*, MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B-cell development. EMBO J, 2011, 30(11): 2281-2293. IF=11.4