主持科研课题
1．国家自然科学基金面上项目，82173829，靶向抑制周期蛋白依赖性激酶4/6促进溶瘤病毒抗恶性胶质瘤的效应及其机制研究，2022/01- 2025/12，55万，在研，主持。

2. 国家自然科学基金青年项目，81803568，cAMP信号激动剂对恶性胶质瘤血管新生和血管正常化的影响及机制研究，2019/01-2021/12，21万元，结题，主持。

3. 广东省自然科学基金面上项目，2018A030310099，cAMP信号激动诱导恶性胶质瘤细胞血管正常化及机制研究，2018/06-2021/06，10万元，结题，主持。

4.深圳市优秀科技创新人才培养项目，工程化溶瘤病毒克服PTEN缺陷胶质瘤免疫治疗抵抗的效应和机制, RCBS20200714114923232，2021/03-2023/03，20万元，在研，主持。

5. 博士后科学基金特别资助，2019T120772，溶瘤病毒重塑PTEN缺失胶质瘤免疫微环境及机制研究，2019/06-2021/06，18万元，结题，主持。

6. 博士后科学基金面上资助，2019M653171，cAMP信号抑制胶质瘤血管拟态和血管生成及机制研究，2019/06-2021/06，8万元，结题，主持。

7. 深圳市科技计划自由探索项目，JCYJ20170818162249554，诱导分化剂对恶性胶质瘤血管生长和成熟的影响及其机制研究，2018/03-2021/03， 25万元，结题，主持。

代表性论文

1. Zixi Qin^# Youwei Huang^#, Zeying Li^#, Guopeng Pan, Liangying Zheng, Xiao Xiao, Fang Wang, Jiahong Chen, Xueqin Chen, Xi Lin, Kai Li, Guangmei Yan, Haipeng Zhang*, Fan Xing*. Glioblastoma vascular plasticity limits effector T cell infiltration and is blocked by cAMP activation. Cancer Immunology Research. 2023. Accepted (通讯作者，IF=12.02, 医学一区TOP)

2. Jingshu Xiao^#, Jiangming Liang^#, Junjie Fan，Panpan Hou, Xiaodong Li，Haipeng Zhang，Kai Li，Lang Bu, Miao He, Ping Li, Yongheng Zhong, Liping Guo, Penghui Jia, Qiaoqiao Xiao, Junyu Wu, Hong Peng1, Chunmei Li, Fan Xing* and Deyin Guo*. CDK4/6 inhibition enhances oncolytic therapy by potentiating tumor-selective cell killing and T cell activation in glioblastoma. Cancer Research, 2022 Sep 16;82(18):3359-3374.（共同通讯作者排第二，IF= 13.312，医学一区TOP)

3. Fan Xing^#, Jingshu Xiao^#, Junyu Wu^#, Jiaming Liang, Xiaoyu Lu, Liping Guo, Ping Li, Panpan Hou, Chunmei Li, Deyin Guo*. Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma, Signal Transduction and Targeted Therapy, 2021 Jul 28;6(1):275. (第一作者，IF= 38.104, 医学一区TOP)

4. Fan Xing^#, Yizhao Luan^#, Jing Cai^#, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan, Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao, Pengxin Qiu, Xingwen Su, Wei Yin, Jun Hu, Zhongping Chen, Ke Sai, Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu, Dongbing Liu, Shiyuan Cheng, Zhi Xie*, Wenbo Zhu*, Guangmei Yan*. The Anti-Warburg Effect Elicited by the cAMP-PGC1 alpha Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes, Cell Reports, 2017 Jan 10;18(2):468-481. （第一作者，IF= 9.995，生物学一区TOP）

5. Junyu Wu^#, Chunyan Wu^#, Fan Xing^#, Liu Cao^#, Weijie Zeng, Liping Guo, Ping Li1, Yongheng Zhong, Hualian Jiang, Manhui Luo, Guang Shi, Lang Bu, Yanxi Ji, Panpan Hou, Hong Peng, Junjiu Huang, Chunmei Li, Deyin Guo*. Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. Cell Research. 2021 Sep;31(9):998-1010. (共同第一作者排第三，IF= 46.297，生物学一区TOP)

6. Kai Li^#, Cheng Hu^#, Fan Xing^#, Mingshi Gao, Jiankai Liang, Xiao Xiao, Jing Cai, Yaqian Tan, Jun Hu, Wenbo Zhu, Wei Yin, Yuan Li, Wenli Chen, Bingzheng Lu, Jialuo Mai, Pengxin Qiu, Xingwen Su, Guangmei Yan, Haipeng Zhang*, Yuan Lin*. Deficiency of the IRE1 alpha-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1, Journal of Virology, 2018 Feb 26;92(6): e01331-17. (共同第一作者，IF= 6.549，医学二区)

7. Haipeng Zhang^#, Kai Li^#, Yuan Lin^#, Fan Xing, Xiao Xiao, Jing Cai, Wenbo Zhu, Jiankai Liang, Yaqian Tan, Liwu Fu, Fang Wang, Wei Yin, Bingzheng Lu, Pengxin Qiu, Xingwen Su, Shoufang Gong, Xuetao Bai, Jun Hu*, Guangmei Yan*. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma, Science Translational Medicine, 2017 Aug 23; 9(404):eaam7996. (IF= 19.319, 医学一区)

8. Xiao Xiao^#, Jiankai Liang^#, Chunlong Huang, Kai Li, Fan Xing, Wenbo Zhu, Ziqing Lin, Wencang Xu, Guangen Wu, Jifu Zhang, Xi Lin, Yaqian Tan, Jing Cai, Jun Hu, Xueqin Chen, Youwei Huang, Zixi Qin, Pengxin Qiu, Xingwen Su, Lijun Chen, Yuan Lin, Haipeng Zhang*, Guangmei Yan*. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage, Nature Communications, 2018 Oct 18; 9(1):4342.  （IF= 17.694，综合一区TOP）

9. Kai Li^#, Jian-lin Wu^#, Baifu Qin, Zongmin Fan, Qin Tang, Weisi Lu, Haipeng Zhang, Fan Xing, Manqi Meng, Shaomin Zou,Wenxia Wei, Honglei Chen, Jian Cai, Huaiming Wang, Hui Zhang, Jiayue Cai, Ling Fang, Xiqing Bian, Chuangqi Chen,Ping Lan, Bart Ghesquière, Lekun Fang* and Mong-Hong Lee*. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer. Cell Research, 2020 Feb; 30(2):163-178. （IF=46.297，生物学一区TOP)

10. Panpan Hou^#, Penghui Jia^#, Kongxiang Yang^#, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu , Deyin Guo* An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. PNAS，2021 Jan 19;118(3):e2015416118. （IF=11.205，综合一区TOP)

11. Kai Li^#, Haipeng Zhang^#, Jianguang Qiu , Yuan Lin , Jiankai Liang , Xiao Xiao , Liwu Fu , Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin , Bingzheng Lu , Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li , Wenli Chen, Pengxin Qiu , Xingwen Su, Guangping Gao, Phillip W L Tai , Jun Hu*, Guangmei Yan* Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1. Mol Ther. 2016 Feb;24(1):156-65. （IF= 12.91，医学一区TOP)

12. Ping Li^#, Junyu Wu^#,*, Shujie Liu, Ruiqing Lu, Hualian Jiang, Niu Wang, Manhui Luo, Liping Guo, Jingshu Xiao, Lang Bu, Lihong Liu, Fan Xing, Hong Peng, Chunmei Li, Lan Ma, Bo Zhao, Zhongwei Zhou, Deyin Guo*. The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription. PNAS，2022 Dec 6;119(49):e2205013119. （IF=11.205，综合一区TOP)

13. Weijie Zeng^#, Fan Xing^#, Yanxi Ji, Sidi Yang, Tiefeng Xu, Siyao Huang, Chunmei Li, Junyu Wu*, Liu Cao*, Deyin Guo*. Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2.  Front Cell Infect Microbiol. 2022 Jun 10;12:911313. （共同第一作者，IF= 5.4267，二区)