方翔
工学博士、助理研究员
- 教育/工作经历：
- 主要研究方向：
采用生物信息学和分子生物力学研究方法，对精子结构蛋白缺陷导致精子形态和功能异常的分子机制，以及基因缺陷导致小儿脑瘫的分子机制进行了深入研究。在Brain、Redox Biology、Development等期刊发表研究论文十余篇。获得国家发明专利授权1项。
- 研究关键词（中英文）
主要学术任职:
广东省生物医学工程学会 理事
主持科研课题:
1. 广东省自然科学基金项目，2214050003307，精子纤维鞘蛋白Fsip1通过鞭毛内输运途径参与精子形成过程的分子机制研究，2022/01-2024/12，主持。
2. 广东省自然科学基金项目，2018A030313538，α6螺旋的解折叠对α6和spacer结合的影响及其分子机制，2018/05-2021/04，主持。
代表性论文:
(1) Yaser Gamallat, Xiang Fang#, Hanran Mai, Xiaonan Liu, Hong Li, Pei Zhou, Dingding Han, Shuxin Zheng, Caihua Liao, Miaomiao Yang, Yan Li, Liandong Zuo, Ling Sun, Hao Hu*, and Na Li*, Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice, Redox Biol, 2021 (IF= 11.4).
(2) Na Li, Pei Zhou#, Hongmei Tang#, Lu He#, Xiang Fang#, Jinxiang Zhao, Xin Wang, Yifei Qi, Chuanbo Sun, Yunting Lin, Fengying Qin, Miaomiao Yang, Zhan Zhang, Caihua Liao, Shuxin Zheng, Xiaofang Peng, Ting Xue, Qianying Zhu, Hong Li, Yan Li, Liru Liu, Jingyu Huang, Li Liu, Changgeng Peng, Angela M Kaindl, Jozef Gecz, Dingding Han*, Dong Liu*, Kaishou Xu*, Hao Hu*, In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy, Brain, 2022 (IF= 14.5).
(3) Xiang Fang, Yaser Gamallat#, Zhiheng Chen, Hanran Mai, Pei Zhou, Chuanbo Sun, Xiaoliang Li, Hong Li, Shuxin Zheng, Caihua Liao, Miaomiao Yang, Yan Li, Zeyu Yang, Caiqi Ma, Dingding Han, Liandong Zuo, Wenming Xu, Hao Hu, Ling Sun*, Na Li*. Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation, Development. 2021 (IF= 4.6).
(4) Xiang Fang, Jiangguo Lin#, Ying Fang*, Jianhua Wu*, Prediction of spacer-α6 complex: a novel insight into binding of ADAMTS13 with A2 domain of von Willebrand factor under forces, Scientific Reports, 2018 (IF= 4.6).
(4) Ling Sun*, Xiang Fang#, Zhiheng Chen, Hanwang Zhang, Zhan Zhang, Pei Zhou, Ting Xue, Xiangfang Peng, Qiannying Zhu, Minna. Yin, Chunlin. Liu, Yu. Deng, Hao Hu, Na Li*, Compound heterozygous ZP1 mutations cause empty follicle syndrome in infertile sisters, Human Mutation, 2019 (IF= 3.9).