广东省医学科学院

PI 团队杰出人才

张学礼

生物信息学博士、副研究员

教育/工作经历：

2023年12月至今：广东省人民医院，医学研究部，副研究员 
2020年9月2023年12月：广东省人民医院，医学研究部，助理研究员 
2016年7月至2020年6月：瑞典厄勒布鲁大学，医学院，博士

主要研究方向：

研究兴趣为基于复杂网络探究疾病的共病关系并寻找新型组合标志物，构建了多个生物标志物数据库及预测模型，发表SCI论文50余篇，其中以第一/通讯作者在Intensive Care Medicine，iMeta，BMC Medicine，Bioinformatics，NPJ Aging, Journal of Translational Medicine等知名杂志发表论文10余篇，被Nature Reviews Clinical Oncology，Nature Reviews Gastroenterology & Hepatology等高水平杂志引用。

研究关键词（中英文）

生物信息学，共病，网络，生物标志物，数据库，模型
Bioinformatics, Comorbidity, Network, Biomarker, Database, Model

主要学术任职

1. 中国生物信息学会（筹）“转化信息学与数据共享安全”专委会委员

2. SCI杂志iMeta青年编委

3. iMeta, Database, iScience, NRR, Medicine Advances, BMC系列等杂志审稿人

主持科研课题

1. 国家自然科学基金青年基金，2023-01至2025-12，30万，在研，主持

2. 广东省自然科学基金面上项目，2025-01至2027-12，10万，在研，主持

3. 广州市基础与应用基础研究专题青年博士“启航”项目, 2025-01至2026-12，5万，在研，主持

4. 广东省医学科学基金，2024-07至2026-06，1万，在研，主持

代表性论文

1. Xueli Zhang, Min Li, Siting Ye, Ke Shen, Haining Yuan, Shoaib Bakhtyar,Qiliang Peng, Yongsheng Liu, Yingying Wang, Manshi Li, Chi Zhang, Yixin Wang, Xiaohe Bai, Shunming Liu, Ke Zhao, Bairong Shen, Dirk Repsilber, Guang Hu, Hong Zhang, Xiao-Feng Sun. CBD2: A Functional Biomarker Database for Colorectal Cancer. iMeta, 2024, 3(1), e155. (IF=23.8)

2. C Zhang#, Xueli Zhang#, Z Sun, X Liu, and B Shen. MetaSepsisBase: a biomarker database for systems biological analysis and personalized diagnosis of heterogeneous human sepsis. Intensive Care Medicine, 2023, 49(8), 1015. (IF=41.8)

3. Xueli Zhang, Kong L, Liu S, Zhang X, Shang X, Zhu Z, Huang Y, Ma S, Jason H, Kiburg KV, Zheng C, Hu Y, Li C, Wu G, Liang Y, He M, Wang Y, Bai X, Shi D, Wang W, Zhang C, Zhao K, Yuan H, Hu G, Hu Y, Liang H, Yu H, Zhang L, He M. EBD: an eye biomarker database. Bioinformatics, 2023,4;39(5):btad194. (IF=6.9)

4. Xianwen Shang#, Xueli Zhang#, Yu Huang, Zhuoting Zhu, Xiayin Zhang, Shunming Liu, Jiahao Liu, Shulin Tang, Wei Wang, Honghua Yu, Zongyuan Ge, Xiaohong Yang, Mingguang He. Temporal trajectories of important diseases in the life-course and premature mortality in the UK Biobank. BMC Medicine, 2022; 20(1):185 (IF=11.8)

5. Xueli Zhang, Yu Huang, Shunming Liu, Shuo Ma, Min Li, Zhuoting Zhu, Wei Wang, Xiayin Zhang, Jiahao Liu, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He, Xianwen Shang. Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes. Journal of Translational Medicine, 2024, 22 (1), 1-13. (IF=6.1)

6. Siting Ye, Shuo Ma, Shunming Liu, Yu Huang, Dantong Li, Min Li, Ting Su, Jing Luo, Chi Zhang, Danli Shi, Lianting Hu, Lei Zhang, Honghua Yu, Mingguang He, Xianwen Shang, Xueli Zhang*. Shared whole environmental etiology between Alzheimer's disease and Age-related macular degeneration. NPJ Aging, 2024, 10: 36. (IF=5.0)

7. Xueli Zhang*, Dantong Li, Siting Ye, Shunming Liu, Shuo Ma, Min Li, Qiliang Peng, Lianting Hu, Xianwen Shang, Mingguang He, Lei Zhang. Decoding the Genetic Comorbidity Network of Alzheimer's Disease. BioData Mining, 2024, 17(1):40. (IF=4.0)

8. Xueli Zhang, Hong Zhang, Bairong Shen, and Xiao-Feng Sun. Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays. Cancers, 2022, 14(11), 2664. (IF=6.6)

9. Xueli Zhang, Zhuoting Zhu, Yu Huang, Xianwen Shang, Terence J O’Brien, Patrick Kwan, Jason Ha, Wei Wang, Shunming Liu, Xiayin Zhang, Katerina V Kiburg, Yining Bao, Jing Wang, Honghua Yu, Mingguang He, Lei Zhang. Shared genetic etiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes. BMJ Neurology Open, 2024, 6:e000570. (IF=2.7)

10. Xiayin Zhang, Shan Wang, Shunming Liu, Zijing Du, Guanrong Wu, Yingying Liang, Yu Huang, Xianwen Shang, Yijun Hu, Zhuoting Zhu, Wei Sun, Xueli Zhang*, Honghua Yu. Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults. Human Genomics, 2024, 18, 39. (IF=4.5)

11. Xueli Zhang, Xiao-Feng Sun, Yang Cao, Benchen Ye, Qiliang Peng, Xingyun Liu, Bairong Shen and Hong Zhang. CBD: a biomarker database for colorectal cancer. Database (Oxford), 2018, 2018: bay046. (IF=5.8)

12. Xueli Zhang, Hong Zhang, Bairong Shen, and Xiao-Feng Sun. Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications. Cancers, 2020, 12, 341. (IF=6.6)

13. Xueli Zhang, Hong Zhang, Bairong Shen, and Xiao-Feng Sun. Chromogranin-A expression as a novel biomarker for early diagnosis of colon cancer patients. Int J Mol Sci, 2019; 20. (IF=6.2)

14. Xueli Zhang, Xiao-Feng Sun, Bairong Shen and Hong Zhang. Potential applications of DNA, RNA and protein biomarkers in diagnosis, therapy and prognosis for colorectal cancer: a study from databases to AI-assisted verification. Cancers, 2019, 11, 172. (IF=6.6)

15. Chunwen Zheng, Shunming Liu, Xiayin Zhang, Yunyan Hu, Xianwen Shang, Zhuoting Zhu, Yu Huang, Wu Guanrong, Yu Xiao, Zijing Du, Yingying Liang, Daiyu Chen, Siwen Zang, Yijun Hu, Mingguang He, Xueli Zhang*, Honghua Yu. Shared genetic architecture between the two neurodegenerative diseases: Alzheimer's disease and glaucoma. Frontiers in Aging Neuroscience. 2022; 880587. (IF=5.7)

16. Xingyun Liu#, Xueli Zhang#, Jing Chen, Benchen Ye, Shumin Ren, Yuxin Lin, Xiao-Feng Sun, Hong Zhang, Bairong Shen. CRC-EBD: epigenetic biomarker database for colorectal cancer. Frontiers in Genetics, 2022; 11, 907. (IF=4.8)

17. Min Li, Shunming Liu, Shuo Ma, Xianwen Shang, Xiayin Zhang, Ha Jason, Yu Huang, Katerina Kiburg, Ke Zhao, Guang Hu, Lei Zhang, Honghua Yu, Mingguang He, Xueli Zhang*. BMJ Open Ophthalmology, 2024;9(1), e001915. (IF=2.0)