王文标
广东省人民医院医学研究部，副研究员
- 教育/工作经历：
2021-至今，广东省人民医院医学研究部，副研究员 2019-2021，香港中文大学医学部，香江学者 2017-2021，暨南大学生命科学与技术学院，博士后 2012-2017，武汉大学生命科学学院， 博士 2008-2012，武汉大学生命科学学院， 本科
- 主要研究方向：
1、NLRP3炎症小体激活的具体机制； 2、病毒宿主互作与致病机制； 3、TGF-β/Smad3调控肾脏纤维化的具体机制。
- 研究关键词（中英文）
学术任职：
1、广东省病理生理学会第八届理事会理事。
承担或参与项目
1. 第11批中国博士后科学基金特别资助，2018T110923，2018.07-2020.09，15万元，结题，主持；
2. 国家自然科学基金青年项目，81902053, 寨卡病毒感染调控胎盘屏障的分子机制，2020.01-2022.12，21万元，结题，主持；
3. 2019年度中国博士后"香江学者计划”, 2019052；
4.广东省人民医院高水平引进人才配套科研经费，KY012021438,2021.8.17-2026.8.16, 200万元，在研，主持；
5. 国家自然科学基金重点项目，81730061，RNA病毒激活炎症反应调控血液屏障的分子机制，2018.01-2022.12,283万元，结题，参与；
6. 国家自然科学基金面上项目，82072834，m5C RNA甲基化新型识别蛋白EIF4A1在膀胱癌发生发展中的作用和机制研究，2021.01-2024.12，55万元，在研，参与；
7. 国家自然科学基金青年项目，31800147，肠道病毒71型诱导外泌体促进血脑屏障通透性的分子机制研究，2019.01-2021.12，25万元，结题，参与。
近5年代表性科研成果（*为通讯作者）：
1. Wenbiao Wang#, Junzhe Chen#, Dingwen Hu, Pan Pan, Liying Liang, Wenjing Wu, Ying Tang, Xiao-ru Huang, Xueqing Yu**, Jianguo Wu**, Hui-yao Lan*. SARS-CoV-2 N protein induces acute kidney injury via Smad3-dependent G1 cell cycle arrest mechanism. Advanced Science. 2022, 9(3).[IF: 16.8 ]
2. Wenbiao Wang#, Geng Li#, De Wu#, Zhen Luo#, Pan Pan, Mingfu Tian, Yingchong Wang, Feng Xiao, Aixin Li, Kailang Wu, Xiaohong Liu, Lang Rao, Fang Liu*, Yingle Liu*, Jianguo Wu*. Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion.Nat Commun 2018; 9:106. [IF:12.353]
3. Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu, Huiyao Lan*, Kailang Wu*, Jianguo Wu*. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC biology 2020;18(1):1-22. [IF:7.43]
4. Wenbiao Wang#, Dingwen Hu#, Caifeng Wu, Yuqian Feng, Aixin Li, Weiyong Liu, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Muhammad Adnan Shereen, Weijie Chen, Pan Pan, Pin Wan, Kailang Wu*, Jianguo Wu*. STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. PLoS Pathog 2020; 16(3):e1008335. [IF:6.82]
5. Wenbiao Wang#, Feng Xiao#, Pin Wan, Pan Pan, Yecheng Zhang, Fang Liu, Kailang Wu, Yingle Liu*, Jianguo Wu*. EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex. PLoS Pathog 2017; 13(1):e1006123. [IF:6.6]
6. Lang Rao#, Wenbiao Wang#, Qian-Fang Meng, Mingfu Tian, Bo Cai, Yingchong Wang, Aixin Li, Minghui Zan, Feng Xiao, Lin-Lin Bu, Geng Li, Andrew Li, Yingle Liu, Shi-Shang Guo, Xing-Zhong Zhao, Tza-Huei Wang, Wei Liu*, Jianguo Wu*. A biomimetic nanodecoy traps Zika virus to prevent viral infection and fetal microcephaly development. Nano Lett 2018 Dec 13. doi:10.1021/acs.nanolett.8b03913. [IF:12.080]
7. Dingwen Hu, Yingchong Wang, Aixin Li, Qin Li, Caifeng Wu, Muhammad Adnan Shereen, Shanyu Huang, Kailang Wu, Ying Zhu*, Wenbiao Wang*, Jianguo Wu*. LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination. Virulence 2021 Jul;12(1):1795-1807. [IF: 5.882 ]
8. Yuting Chen, Zhaoxin Li, Pan Pan, Zizhao Lao, Jiangtao Xu, Zonghui Li, Shaofeng Zhan, Xiaohong Liu, Yina Wu*, Wenbiao Wang*, Geng Li*. Cinnamic acid inhibits Zika virus by inhibiting RdRp activity. Antiviral Res 2021; Aug; 192:105117. [IF: 5.97 ]
9. Aixin Li#, Wenbiao Wang#, Yingchong Wang#, Keli Chen, Feng Xiao, Dingwen Hu, Lixia Hui, Weiyong Liu, Yuqian Feng, Geng Li, Qiuping Tan, Yingle Liu, Kailang Wu*, Jianguo Wu*. NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling. Frontiers in Immunology 2020;11:51. [IF:7.56]
10. Zhen Luo#, Rui Su#, Wenbiao Wang#, Yicong Liang, Xiaofeng Zeng, Muhammad Adnan Shereen, Nadia Bashir, Qi Zhang, Ling Zhao, Kailang Wu, Yingle Liu, Jianguo Wu*. EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production. PLoS Pathog 2019; 15(11):e1008142. [IF:6.2]